The primary scientific focus of our laboratory is directed towards gaining
an understanding of the molecular and transcriptional mechanisms that
drive cell specification and differentiation of the endothelial cells.
Currently, our research efforts are centered on three different genes and
their protein products: 1) Lipid phosphate phosphatase-3 (LPP3, also
called PPAP2b), and transcription factors 2) NANOG and 3) Kruppel Like
Factor-4 (KLF4), in relation to neovascularization and regenerative
medicine. Accordingly, we have created unique reagents and tools to
investigate the biology of these genes and proteins using stem cells,
endothelial cells, and small animals such as mice. The long-term
translational research goal of our laboratory is to identify and
characterize how defects in key regulatory circuits lead to the
progression to unwanted angiogenesis (or neovascularization) which may aid
in the development of novel therapeutic approaches for cardiovascular
disease and stroke, acute lung injury and cancer.