Ongoing projects in the laboratory are geared toward unraveling the mechanisms that lead to disruption and subsequent repair of the
endothelial barrier. Defining these mechanisms will allow us to identify potential targets for therapeutic intervention in cases of tissue
inflammation, the hallmark of inflammatory diseases such as the Acute Respiratory Distress Syndrome (ARDS). Studies include the use of state-of-the-art
cell imaging techniques, expression of mutant constructs, and siRNA-induced down regulation of genes in endothelial cells and intact lungs isolated from
several genetic mouse models.