My lab is pursuing research in three related areas:
We are studying receptor-induced signaling pathways that regulate the barrier properties of endothelial and epithelial cells. These findings provide insights that are important to our
understanding of normal and pathological conditions of the lung vasculature. A primary objective of the laboratory is to develop and test novel strategies for drug and gene delivery. We are interested in targeting
cells specifically of the vessel wall which are critical elements involved in the pathogenesis of a variety of inflammatory diseases, including atherosclerosis, and of cancer metastasis. We are also studying the
effects of exogenous endothelial progenitor cells on damaged endothelium. Finally, we are studying transcriptional regulation of the endothelial adhesion molecule ICAM-1 to develop strategies for controlling its
expression and regulating detrimental leukocyte trafficking across the vascular endothelium.