Thromboxane receptor (TPR) signaling is known to modulate human blood platelet function and to be directly involved in the development of
thromboembolic diseases including heart attack and stroke. In addition, recent information has linked the TPR pathway with myelinating cell function in the central
nervous system, i.e., oligodendrocyte proliferation, survival and myelin basic protein synthesis. Our research program investigates the underlying mechanisms by
which TPRs signal in each of these important cell types. To this end, pharmacological, biochemical, immunological and genetic approaches are used to elucidate the
molecular interactions associated with the TPR signal transduction components, and how these interactions lead to the regulation of platelet and oligodendrocyte
function in both normal and disease states.